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Updated: Jun 28, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Recent aspects of medical care of malignant melanoma
Patrick Terheyden1, Wolfgang Tilgen, Axel Hauschild
1Department of Dermatology, University Clinic of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. patrick.terheyden@uk-sh.de
Abstract:
Recent developments in the epidemiology, diagnosis and therapy of malignant melanoma are reviewed, with particular attention paid to established standards of care. When melanoma metastases are inoperable, they respond poorly to the various chemotherapy strategies, so that additional improvements are critically needed. Cytotoxic T-lymphocyte antigen-4 antibodies, multikinase inhibitors, anti-apoptotic strategies and several other approaches are in progress in Phase III trials both as monotherapy as well as in combination with standard chemotherapy.
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