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Skin toxicity of anti-cancer therapy

Jens Ulrich1, Jörg T Hartmann, Wolfgang Dörr

  • 1Department of Dermatology and Allergology, Quedlinburg Clinic, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|November 11, 2008
PubMed

Insights

Cancer treatments like chemotherapy and radiation can cause common skin side effects affecting hair and nails. This review covers these cutaneous reactions and changes from targeted therapies.

Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Antineoplastic treatments frequently cause cutaneous side effects impacting hair follicles and nails.
  • These skin changes present diagnostic and therapeutic challenges in cancer care.

Purpose of the Study:

  • To review common cutaneous reactions to chemotherapy, radiation therapy, and targeted agents.
  • To identify causative agents and characteristic skin changes associated with these cancer treatments.

Main Methods:

  • Literature review of cutaneous reactions to antineoplastic treatments.
  • Analysis of adverse events from chemotherapy, radiation, and molecular-driven targeted therapies.

Main Results:

  • Chemotherapy, radiation, and targeted agents induce a range of skin and adnexal changes.
  • Specific causative agents and characteristic dermatological manifestations are detailed.

Conclusions:

  • Understanding these treatment-related skin changes is crucial for patient management.
  • Further research may improve diagnostic and therapeutic strategies for cutaneous side effects.

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