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Related Experiment Video

Updated: Jun 28, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Multidimensional Adherence Classification System: initial development with adolescent transplant recipients.

Laura E Simons1, Jordan Gilleland, Ronald L Blount

  • 1Department of Psychiatry, Children's Hospital Boston, Boston, MA, USA. laura.simons@childrens.harvard.edu

Pediatric Transplantation
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Adolescent organ transplant recipients face high rates of medication non-adherence. A new assessment tool, the Medication Adherence Composite Score (MACS), shows promise in identifying non-adherent patients and predicting outcomes.

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Last Updated: Jun 28, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

  • Pediatric Solid Organ Transplantation
  • Adolescent Health
  • Medication Adherence Research

Background:

  • Medication non-adherence is a significant threat to graft survival in adolescent solid organ transplant recipients.
  • Accurate assessment of medication adherence is crucial for intervention but challenging.
  • Existing methods like self-report and drug assays have limitations.

Purpose of the Study:

  • To introduce and evaluate the Medication Adherence Composite Score (MACS) for assessing adherence in adolescent solid organ transplant recipients.
  • To determine the non-adherence rate in a sample of adolescent solid organ transplant recipients using the MACS.
  • To explore the relationship between adherence categories defined by the MACS and clinical outcomes such as rejection and mortality.

Main Methods:

  • Development and implementation of the Medication Adherence Composite Score (MACS), integrating self-report and drug assay data.
  • Study sample comprised 82 adolescent solid organ transplant recipients.
  • Analysis of the association between MACS-defined adherence categories and the occurrence of rejection episodes and mortality.

Main Results:

  • The non-adherence rate among the studied adolescent solid organ transplant recipients was 61% when assessed by the MACS.
  • Initial data suggest the MACS is a promising system for adherence assessment.
  • Membership in the 'Genuinely Non-adherent' category was significantly associated with increased risk of rejection episodes and mortality.

Conclusions:

  • The Medication Adherence Composite Score (MACS) offers a potentially more robust method for assessing medication adherence in adolescent transplant recipients.
  • The high non-adherence rate identified by MACS highlights a critical area for clinical attention.
  • The MACS's ability to predict adverse outcomes underscores its clinical utility in managing this vulnerable population.