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PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid

Hannah J Rohe1, Ikhlas S Ahmed, Katherine E Twist

  • 1Department of Molecular and Biomedical Pharmacology, University of Kentucky, MS-305 UKMC, Lexington, Kentucky 40536, United States.

Pharmacology & Therapeutics
|November 11, 2008
PubMed

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G Protein-coupled Receptors01:15

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G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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