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Updated: Jun 28, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Engineering natural products using combinatorial biosynthesis and biocatalysis.

Hui Zhou¹, Xinkai Xie, Yi Tang

¹Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.

Current Opinion in Biotechnology

|November 11, 2008

Summary

Combinatorial biosynthesis modifies natural product pathways to create novel compounds and enzymes. These biocatalysts offer powerful tools for synthesizing new and existing therapeutics, advancing drug discovery.

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Area of Science:

Biochemistry
Synthetic Biology
Pharmacology

Background:

Biologically active natural products are synthesized by host organisms via dedicated biosynthetic pathways.
These pathways can be engineered using combinatorial biosynthesis to generate novel compounds with improved properties.
Enzymes from these pathways serve as valuable biocatalysts for drug synthesis.

Purpose of the Study:

To review recent advancements in exploring natural product biosynthetic pathways.
To highlight the discovery of new compounds and novel enzymes.
To showcase the utility of these enzymes as biocatalysts.

Main Methods:

Exploration of natural product biosynthetic pathways.
Application of combinatorial biosynthesis techniques.
Biocatalyst harvesting and utilization.

Main Results:

Identification of novel natural products with potential therapeutic applications.
Discovery of new enzymes with unique catalytic activities.
Demonstration of biocatalysts for synthesizing existing and novel therapeutics.

Conclusions:

Natural product biosynthetic pathways are a rich source for drug discovery and development.
Combinatorial biosynthesis enables the creation of diverse chemical structures.
Enzymes from these pathways represent powerful and versatile biocatalysts for pharmaceutical applications.