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Updated: Jun 28, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Lupus registries: evolution and challenges.

Liang-Jing Lu1, Daniel J Wallace, Sandra V Navarra

  • 1Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Seminars in Arthritis and Rheumatism
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Lupus registries are crucial for real-world clinical research, offering valuable data for systemic lupus erythematosus studies. These evolving databases provide insights into epidemiology, genetics, and outcomes, despite ongoing challenges.

Related Experiment Videos

Last Updated: Jun 28, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Area of Science:

  • Rheumatology
  • Clinical Epidemiology
  • Data Science

Background:

  • Systemic lupus erythematosus (SLE) research relies on robust data collection.
  • Lupus registries have become vital tools in understanding this complex autoimmune disease.
  • Their evolution reflects advancements in clinical research methodologies.

Purpose of the Study:

  • To review the current status and evolution of lupus registries.
  • To highlight their importance in clinical lupus research.
  • To discuss advances and future directions, including opportunities and challenges.

Main Methods:

  • Literature review from PubMed database (pre-June 2008).
  • Keywords: systemic lupus erythematosus, registry, cohort, database.
  • Analysis based on a custom template categorizing registry types.

Main Results:

  • Registries offer large subject numbers and real-world data for SLE patients.
  • Registry data are essential for clinical studies, especially those unsuitable for RCTs.
  • Recognized contributions in epidemiology, genetics, diversity, clinical features, and outcomes.

Conclusions:

  • Lupus registries have achieved significant success and high standards.
  • They continue to evolve, addressing complex research questions with increasing sophistication.
  • Ongoing efforts are needed to normalize ethical and legal frameworks for registries.