Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sea level rise and fall north of Greenland reorganize Arctic freshwater export to North Atlantic.

Nature communications·2026
Same author

Sunburn-induced bark damage facilitates <i>Eutypella decipiens</i> infection of <i>Carpinus betulus</i> in Serbian urban landscapes.

Frontiers in plant science·2026
Same author

Global climate mode resonance due to rapidly intensifying El Niño-Southern Oscillation.

Nature communications·2025
Same author

The virome of the panglobal, wide host-range plant pathogen <i>Phytophthora cinnamomi</i>: phylogeography and evolutionary insights.

Virus evolution·2025
Same author

Preserving the Biologically Coherent Generic Concept of <i>Phytophthora</i>, "Plant Destroyer".

Phytopathology·2025
Same author

Intraspecific Variation and Recent Loss of Ancient, Conserved Effector Genes in the Sudden Oak Death Pathogen <i>Phytophthora ramorum</i>.

Molecular plant-microbe interactions : MPMI·2025

Related Experiment Videos

Atopic dermatitis: therapeutic concepts evolving from new pathophysiologic insights.

Thomas Jung1, Georg Stingl

  • 1Novartis Pharma Development, Immunology and Infectious Diseases Franchise, Basel, Switzerland. thomas.jung@novartis.com

The Journal of Allergy and Clinical Immunology
|November 11, 2008
PubMed
Summary

New insights into atopic dermatitis (AD) reveal the importance of the skin barrier and immune interactions. Research explores novel treatments targeting filaggrin mutations and antimicrobial peptides beyond the T(H)1/T(H)2 model.

Related Experiment Videos

Area of Science:

  • Dermatology and Immunology
  • Skin Barrier Research
  • Atopic Dermatitis Pathogenesis

Background:

  • Atopic dermatitis (AD) involves complex interactions between epidermal barrier dysfunction and immune responses.
  • Recent discoveries highlight the role of filaggrin mutations and reduced antimicrobial peptides in AD.
  • Traditional T(H)1/T(H)2 paradigms may not fully explain AD pathogenesis.

Purpose of the Study:

  • To review recent findings on epidermal barrier function in AD.
  • To discuss novel therapeutic strategies targeting barrier defects and immune dysregulation.
  • To explore new concepts for restoring skin homeostasis in AD.

Main Methods:

  • Literature review of recent studies on atopic dermatitis.
  • Analysis of research on epidermal barrier proteins (e.g., filaggrin).
  • Examination of innate and adaptive immune components in AD skin.

Main Results:

  • Loss-of-function mutations in filaggrin are implicated in AD.
  • Diminished expression of antimicrobial peptides is observed in AD skin.
  • Emerging treatments show promise in proof-of-concept trials.

Conclusions:

  • Novel therapeutic targets focus on restoring epidermal barrier integrity.
  • Understanding barrier-immune interactions offers new treatment avenues for AD.
  • Restoring skin homeostasis is key to managing atopic dermatitis effectively.