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Spontaneous coronary artery dissection in a woman with polycystic kidney disease

Charles T Itty1, Ahmad Farshid, Girish Talaulikar

  • 1Department of Cardiology, The Canberra Hospital, Garran, ACT, Australia.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|November 11, 2008
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) patients rarely experience spontaneous coronary artery dissection (SCAD). This case highlights successful percutaneous coronary intervention for SCAD in an ADPKD patient, emphasizing early recognition.

Area of Science:

  • Cardiology
  • Nephrology
  • Genetics

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is associated with vascular abnormalities, including arterial dilatation and dissection.
  • Spontaneous coronary artery dissection (SCAD) is a rare but serious vascular complication.

Observation:

  • A patient with ADPKD presented with acute myocardial infarction due to SCAD.
  • Coronary angiography revealed a long spiral dissection of the left anterior descending artery.

Findings:

  • The patient successfully underwent percutaneous coronary intervention with drug-eluting stents.
  • This represents the first reported case of percutaneous coronary intervention for SCAD in an ADPKD patient.

Implications:

  • Altered polycystin expression in vascular smooth muscle cells may underlie vascular complications in ADPKD.
  • Considering SCAD in the differential diagnosis of acute coronary syndrome in ADPKD patients is crucial for timely management.

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