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A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

Published on: November 6, 2019

Cerebrolysin and morphine decrease glutathione and 5-hydroxyindole acetic acid levels in fasted rat brain.

David Calderón Guzmán¹, Norma Osnaya Brizuela, Raquel García Alvarez

¹Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP), CP 04530, Mexico City, Mexico.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie

|November 11, 2008

Summary

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Morphine and cerebrolysin alter brain biochemical responses to oxidative stress during hypoglycemia. The combination significantly increased lipid peroxidation, indicating potential risks.

Area of Science:

Neuroscience
Biochemistry
Pharmacology

Background:

Hypoglycemia can induce oxidative stress in the brain.
Morphine and cerebrolysin are used in neurological conditions, but their combined effects on oxidative stress are not fully understood.

Purpose of the Study:

To investigate the combined effects of morphine sulphate and cerebrolysin on oxidative damage markers in rats experiencing moderate hypoglycemia.

Main Methods:

Wistar rats were subjected to 48-hour starvation.
Administration of cerebrolysin or morphine sulphate, alone or in combination.
Measurement of glutathione (GSH), 5-hydroxyindoleacetic acid (5-HIAA), lipid peroxidation (TBARS), Na(+)-K(+) ATPase, and total ATPase in brain tissue.

Main Results:

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A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

Published on: November 6, 2019

Both morphine and cerebrolysin, alone or combined, decreased GSH and 5-HIAA levels.
Combined administration of cerebrolysin and morphine significantly increased TBARS levels, indicating enhanced lipid peroxidation.
Morphine alone decreased Na(+)-K(+) ATPase and total ATPase activities, while cerebrolysin and morphine combination increased these activities.

Conclusions:

Morphine and cerebrolysin individually and in combination induce biochemical alterations in the brain.
The combination of morphine and cerebrolysin exacerbates oxidative stress during hypoglycemia, evidenced by increased lipid peroxidation.