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Estimation of renal function -- what is appropriate in cancer patients?
L H Barraclough1, C Field, G Wieringa
1Department of Clinical Oncology, Christie Hospital, Manchester, UK. lisahelenbone@hotmail.com
Aims:
To compare the accuracy of renal assessment in patients with cancer using radioisotope glomerular filtration rate (GFR), urine collection for creatinine clearance, Cockroft-Gault, Modification of Diet in Renal Disease (MDRD) and Wright formulae.
Materials And Methods:
Measurements of isotope GFR from 367 patients were compared with estimates from the described methods (Cockroft-Gault, MDRD, Wright). An analysis including a further 252 patients with an isotope GFR < or = 50 ml/min was also carried out.
Results:
The Wright formula was the most accurate form of estimating renal function for the first study group. The formulae were similar in accuracy in the second study group.
Conclusions:
The Wright formula is the most accurate form of estimation of renal function in comparison with the isotope GFR for cancer patients. When there is a large proportion of patients with a low isotope GFR (< or = 50 ml/min), the formulae have similar accuracy.
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