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Morphological and morphometrical alterations of the osteochondral junction in perinatal necropsies

Ana Karina Marques Salge1, Tarcísio Barcelos Evangelista, Rogério Carrijo Canno

  • 1Nursing School, Goiás Federal University, Goiânia, Brazil. anakarina@fen.ufg.br

Annals of Diagnostic Pathology
|November 11, 2008
PubMed

Insights

Perinatal infant rib osteochondral junction (OCJ) alterations are linked to growth restriction and congenital issues. This study analyzed 254 infant autopsies, identifying specific OCJ morphological changes and their associated factors.

Area of Science:

  • Pediatric Pathology
  • Skeletal Biology
  • Developmental Biology

Background:

  • Osteochondral junction (OCJ) alterations in perinatal infant deaths may indicate intrauterine growth restriction, placental issues, maternal conditions, or congenital abnormalities.
  • Understanding these OCJ changes is crucial for perinatal autopsy analysis.

Purpose of the Study:

  • To identify morphological alterations of the osteochondral junction (OCJ) in autopsied infants.
  • To determine factors associated with the pathogenesis of OCJ alterations.

Main Methods:

  • Analysis of 254 sequentially autopsied infant OCJ samples.
  • Histological examination using Hematoxylin-eosin and Masson's trichrome stains.
  • Measurement of cartilage oligomeric matrix protein (COMP) expression in chondrocytes.

Main Results:

  • 55 out of 254 (22%) infants exhibited OCJ alterations.
  • Common alterations included increased cartilage matrix (ICM), bizarre patterns (BZ), and bone formation closing growth channels (MCO).
  • Proliferative zone length varied significantly across alteration groups, being longer in MCO and ICM, and shorter in BZ.

Conclusions:

  • Osteochondral junction analysis is vital in perinatal autopsies.
  • This study enhances understanding of the mechanisms underlying perinatal OCJ alterations and their potential etiologies.

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