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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 28, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Cutaneous pseudosarcomatous polyp: a recently described lesion.

Helen P Cathro1, James W Patterson, Mark R Wick

  • 1Division of Surgical Pathology and Cytopathology, University of Virginia Medical Center, PO Box 800214, Charlottesville, VA 22908, USA. hpc4f@virginia.edu

Annals of Diagnostic Pathology
|November 11, 2008
PubMed
Summary

Cutaneous pseudosarcomatous polyps are benign skin lesions that appear concerning due to cell variations. Despite their worrisome look, these polyps show no signs of malignancy.

Related Experiment Videos

Last Updated: Jun 28, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

  • Dermatopathology
  • Surgical Pathology

Background:

  • Cutaneous pseudosarcomatous polyps are a recently described lesion in dermatopathology.
  • These benign proliferations exhibit significant cytologic pleomorphism.

Observation:

  • Three cases of cutaneous pseudosarcomatous polyps are presented.
  • Lesions occurred on the back and nasal columella in women aged 30-91.
  • Histologically, polyps showed fibroepithelial architecture with pleomorphic stellate cells in a myxoid stroma.

Findings:

  • Despite marked pleomorphism and atypical mitotic figures in one case, all lesions behaved benignly.
  • Immunohistochemistry revealed vimentin, CD34, and factor XIIIa expression, with absence of smooth muscle actin and desmin.
  • The cells displayed symplastic or pseudomalignant features.

Implications:

  • Cutaneous pseudosarcomatous polyps represent a distinct entity with pseudomalignant potential.
  • Accurate diagnosis is crucial to avoid misclassification as malignancy.
  • Further studies are needed to fully understand the behavior and potential of these lesions.