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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: Jun 28, 2026

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

[Childhood medulloblastoma].

L Yazigi-Rivard¹, C Masserot, J Lachenaud

¹Département d'oncologie pédiatrique, institut Curie, 26, rue ULM, 75231 Paris cedex 05, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|November 11, 2008

Summary

Medulloblastoma, a common childhood brain tumor, is diagnosed via imaging and histology. Treatment involves surgery, radiation, and chemotherapy, with ongoing research to reduce side effects and improve survival.

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Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

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Last Updated: Jun 28, 2026

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

Area of Science:

Pediatric Oncology
Neuro-oncology
Cancer Genetics

Background:

Medulloblastoma is a common malignant childhood brain tumor originating in the cerebellum.
While often sporadic, genetic syndromes like SUFU and Gorlin can predispose individuals to medulloblastoma.
Intracranial hypertension, presenting as headache and vomiting, frequently indicates disease onset, though atypical presentations necessitate prompt neuroradiological evaluation.

Purpose of the Study:

To review the diagnostic approaches for medulloblastoma.
To outline current treatment strategies based on patient risk stratification.
To highlight the importance of managing long-term treatment sequelae.

Main Methods:

Diagnosis relies on brain and spinal MRI for tumor detection and staging, complemented by CSF studies.
Histologic examination confirms medulloblastoma diagnosis.
Risk stratification into standard and high-risk groups guides treatment intensity.

Main Results:

Molecular genetic findings are increasingly important for prognosis and potential targeted therapies.
Treatment for older children typically includes surgery, radiotherapy, and chemotherapy.
Research focuses on reducing craniospinal irradiation (CSI) in standard-risk patients to minimize sequelae.

Conclusions:

Despite advances, long-term sequelae from medulloblastoma treatment remain a significant concern.
Effective management requires vigilant detection and treatment of these sequelae during patient follow-up.
Future therapeutic strategies aim to enhance survival while decreasing treatment-related morbidities.