Chlorpyrifos induces apoptosis in human T cells

Qing Li1, Maiko Kobayashi, Tomoyuki Kawada

  • 1Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, 113-8602 Tokyo, Japan. qing-li@nms.ac.jp

Toxicology
|November 11, 2008
PubMed

Insights

Organophosphorus pesticides (OPs) like chlorpyrifos induce apoptosis, or programmed cell death, in human T cells. This mechanism, involving caspase-3 activation, may explain how OPs inhibit crucial immune responses like cytotoxic T lymphocyte activity.

Area of Science:

  • Immunotoxicology
  • Cell Biology
  • Environmental Health

Background:

  • Organophosphorus pesticides (OPs) are known to inhibit cytotoxic T lymphocyte (CTL) activity.
  • The precise mechanism underlying OP-induced immunomodulation requires further investigation.

Purpose of the Study:

  • To determine if OPs induce apoptosis in T cells.
  • To elucidate the role of caspase-3 activation in OP-induced T cell death.

Main Methods:

  • Jurkat human T cells were exposed to chlorpyrifos in vitro.
  • Cell viability was assessed using MTT and LDH assays.
  • Apoptosis was evaluated through Annexin-V staining, caspase-3 activity assays, and DNA fragmentation analysis.

Main Results:

  • Chlorpyrifos induced T cell death in a dose- and time-dependent manner.
  • Apoptosis was confirmed by Annexin-V staining and DNA fragmentation.
  • Chlorpyrifos increased intracellular active caspase-3 levels, which was inhibited by a caspase-3 inhibitor.

Conclusions:

  • Chlorpyrifos induces apoptosis in human T cells.
  • Caspase-3 activation plays a significant role in chlorpyrifos-induced T cell apoptosis.
  • These findings provide mechanistic insights into OP immunotoxicity.

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