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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...

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Related Experiment Video

Updated: Jun 28, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

[Antibiotics given subcutaneously to elderly].

Antoine Robelet1, Thibaut Caruba, Aline Corvol

  • 1Service Pharmacie, Hôpital Européen Georges Pompidou, Paris, France.

Presse Medicale (Paris, France : 1983)
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Subcutaneous (SC) antibiotics in elderly patients lack sufficient evidence and often lead to complications like skin necrosis, especially with aminoglycosides. Therefore, the SC route is not recommended for this population due to poor data quality and non-specific patient inclusion.

Related Experiment Videos

Last Updated: Jun 28, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Geriatric Pharmacology
  • Infectious Diseases
  • Drug Delivery Systems

Context:

  • Subcutaneous (SC) administration of antibiotics is being explored for potential benefits in elderly patients.
  • However, the existing evidence regarding the efficacy and safety of SC antibiotics in this demographic is limited.
  • Current guidelines and available data do not adequately support this route for geriatric care.

Purpose:

  • To systematically review the available literature on the efficiency and tolerance of antibiotics administered subcutaneously to elderly individuals.
  • To assess the quality of evidence supporting SC antibiotic use in the geriatric population.
  • To identify specific antibiotics and associated complications when administered via the SC route in the elderly.

Summary:

  • A literature review identified seventeen studies on ten antibiotics for SC administration in the elderly.
  • Methodological quality was generally poor (14 studies Level C), with only three antibiotics officially mentioned for SC use.
  • Aminoside SC administration is associated with skin necrosis, and overall evidence for SC antibiotics in the elderly is weak, leading to a non-recommendation for this route.

Impact:

  • Highlights the significant lack of robust evidence for SC antibiotic use in the elderly.
  • Underscores the potential risks, such as local complications and skin necrosis, associated with certain SC antibiotics.
  • Emphasizes the need for further research and cautious consideration by prescribers when deviating from standard administration routes in geriatric patients.