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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

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Published on: April 11, 2014

Ascorbic acid deficiency in bariatric surgical population.

Kevin P Riess1, John P Farnen, Pamela J Lambert

  • 1Department of Medical Education, Gundersen Lutheran Medical Foundation, La Crosse, Wisconsin 54601, USA.

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Ascorbic acid deficiency is common in surgical patients, linked to higher BMI and lower fruit/vegetable intake. Supplementation reduced deficiency rates, but low levels did not impact surgical outcomes.

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Area of Science:

  • Surgical Nutrition
  • Clinical Biochemistry
  • Nutritional Deficiency

Background:

  • Ascorbic acid (vitamin C) deficiency prevalence in surgical patients is largely unknown.
  • The impact of body mass index (BMI) on ascorbic acid levels requires investigation.
  • The association between ascorbic acid deficiency and surgical outcomes needs clarification.

Purpose of the Study:

  • To determine the prevalence of ascorbic acid deficiency in the surgical population.
  • To assess the effect of BMI on ascorbic acid concentrations.
  • To investigate the association between ascorbic acid deficiency and adverse surgical outcomes.

Main Methods:

  • Prospective assessment of preoperative plasma ascorbic acid concentrations in 266 patients aged 20-60 undergoing elective abdominal surgery.
  • Ascorbic acid deficiency defined as concentration ≤0.3 mg/dL; depletion as >0.3-0.59 mg/dL.
  • Analysis of factors including BMI, age, diet, and supplementation.

Main Results:

  • A greater BMI was associated with lower mean ascorbic acid concentrations (P = .021).
  • 36% of patients had low ascorbic acid: 15% deficient, 21% depleted.
  • Younger age, limited fruit/vegetable intake, and lack of supplementation were linked to lower ascorbic acid levels (P < .05).
  • Ascorbic acid supplementation correlated with reduced deficiency and depletion rates (P = .001).

Conclusions:

  • Ascorbic acid deficiency and depletion are prevalent in the surgical population.
  • Factors contributing to low ascorbic acid include younger age, poor diet, lack of supplementation, and higher BMI.
  • Low ascorbic acid concentrations did not appear to influence surgical outcomes.