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Widespread balancing selection and pathogen-driven selection at blood group antigen genes.

Matteo Fumagalli1, Rachele Cagliani, Uberto Pozzoli

  • 1Scientific Institute IRCCS E. Medea, Bioinformatic Lab, 23842 Bosisio Parini (LC), Italy.

Genome Research
|November 11, 2008
PubMed
Summary

Blood group antigen (BGA) gene variations correlate with pathogen richness, indicating their role in host-pathogen evolution. Several BGA genes show evidence of balancing selection, highlighting their importance in human evolutionary history.

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