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Related Concept Videos

Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Jun 28, 2026

Massively Parallel Reporter Assays in Cultured Mammalian Cells
11:03

Massively Parallel Reporter Assays in Cultured Mammalian Cells

Published on: August 17, 2014

MRI reporter genes.

Assaf A Gilad1, Keren Ziv, Michael T McMahon

  • 1Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. assaf@mri.jhu.edu

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Reporter genes enable noninvasive molecular imaging by modulating MRI contrast. This technology is crucial for tracking biological processes like cell trafficking and gene therapy, offering detailed anatomical and functional insights.

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Area of Science:

  • Biomedical imaging
  • Molecular biology
  • Reporter gene technology

Background:

  • Reporter genes are essential tools in noninvasive molecular imaging.
  • They encode proteins that can emit light, bind probes, or alter MRI contrast.
  • Applications include monitoring cell trafficking, gene therapy, and neuronal plasticity.

Purpose of the Study:

  • To review the use of reporter genes for modulating MRI contrast.
  • To highlight strategies for generating MRI contrast using reporter genes.
  • To emphasize the advantages of MRI reporter genes in biomedical research.

Main Methods:

  • Enzyme-catalyzed modification of contrast agents.
  • Utilizing iron-binding and storage proteins for iron accumulation.
  • Developing artificial proteins for chemical exchange saturation transfer (CEST) imaging.

Main Results:

  • Reporter genes offer diverse strategies for MRI contrast generation.
  • These methods allow for the accumulation of iron or modulation of existing contrast agents.
  • CEST imaging utilizes artificial proteins for novel contrast mechanisms.

Conclusions:

  • MRI reporter genes provide a powerful, noninvasive method for molecular imaging.
  • They allow for coregistration with anatomical and functional tissue information.
  • This technology represents a rapidly growing area of scientific interest.