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Published on: May 2, 2025
Susceptibility to hyperglycemia in patients with chronic kidney disease
Walid Shehab-Eldin1, Ali Zaki, Sanaa Gazareen
1Department of Internal Medicine, Faculty of Medicine, Menofia University, Cairo, Egypt.
Background:
Patients with chronic kidney disease (CKD) are susceptible to hyperglycemia.
Aim:
To study the prevalence of pre-diabetes in CKD patients and determine the contribution of insulin resistance (IR) versus beta-cell dysfunction in patients with CKD.
Methods:
45 consecutive nondiabetic CKD patients and 40 healthy subjects were included. Patients were divided into a normoglycemic (NG) and a pre-diabetic (PDM) group. IR was assessed by homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function was assessed by proinsulin/insulin ratio and beta-cell%.
Results:
The prevalence of PDM was 40%. The prevalence of high HOMA-IR was 22.2 and 77.8% in the NG and PDM groups. Compared to NG patients, the PDM group showed higher fasting plasma glucose, HOMA-IR, insulin, and proinsulin, while the prevalence of beta-cell dysfunction of 22.2% was lower than the 37% present in the NG group.
Conclusion:
Increased IR, rather than beta-cell dysfunction, is the primary mechanism of PDM in CKD patients.
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