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Updated: Jun 28, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
A long-term user of cosmetic cream containing estrogen developed breast cancer and endometrial hyperplasia
Shinji Komori1, Yoshihiro Ito, Yuri Nakamura
1Department of Obstetrics and Gynecology, Hyogo College of Medicine, Hyogo, Japan. komor615@hyo-med.ac.jp
Abstract:
A 93-year-old woman was referred to our clinic for abnormal genital bleeding. It was found that she had endometrial hyperplasia and breast cancer. Her uterus was as large as that of a normal adult menstruating woman. She indicated that she had been applying cosmetic cream containing a low concentration of ethynylestradiol to her face and body three times a day for 75 years. It is possible that this long-term use of the ethynylestradiol-containing cream is related to the development of breast cancer and endometrial hyperplasia.
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