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Rhinofacial Conidiobolus coronatus infection presenting with nasal enlargement
N Fischer1, Ch Ruef, C Ebnöther
1Dept. of Medicine, Medical Clinic, University Hospital, Zurich, Zurich, Switzerland.
Infection
|November 11, 2008
Summary
Rhinofacial Conidiobolus coronatus infection, a rare fungal zygomycosis, was successfully treated in a Sudanese patient using terbinafine and itraconazole. Diagnosis was confirmed via culture, though susceptibility testing did not predict the effective therapy.
Area of Science:
- Mycology
- Infectious Diseases
- Dermatology
Background:
- Rhinofacial Conidiobolus coronatus infection is a rare fungal zygomycosis.
- Most human cases occur in periequatorial regions of Africa, Asia, and South America.
- Limited information exists on optimal treatment strategies.
Observation:
- A case of rhinofacial C. coronatus infection in an emigrated Sudanese patient is presented.
- Diagnosis was confirmed by microbiological culture from a tissue biopsy.
- The patient presented with symptoms consistent with rhinofacial mycosis.
Findings:
- Successful treatment was achieved using a 12-month course of terbinafine and itraconazole.
- Antimicrobial susceptibility testing results were not predictive of the optimal therapeutic outcome.
- The patient showed a complete recovery after the treatment regimen.
Implications:
- This case highlights successful treatment outcomes for a rare fungal infection.
- It suggests that combination antifungal therapy can be effective despite non-predictive susceptibility testing.
- Further research is needed to establish definitive treatment guidelines for rhinofacial zygomycosis.
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