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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

[Conservative treatment of pneumatosis intestinalis and pneumoperitoneum after bone marrow transplantation]

C Barceló Cañellas1, C Marhuenda Irastorza, T Olivé

  • 1Departamento de Cirugía Pediátrica, Hospital Infantil Vall d'Hebrón, Barcelona. conxbarcelo@yahoo.es

Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica
|November 13, 2008
PubMed

Insights

Pneumatosis intestinalis (PI) after bone marrow transplantation (BMT) can be managed conservatively. This approach, involving antibiotics and parenteral nutrition, led to good outcomes in six patients without the need for surgery.

Area of Science:

  • Gastroenterology
  • Hematology
  • Radiology

Context:

  • Pneumatosis intestinalis (PI) is a radiological finding that can occur post-bone marrow transplantation (BMT).
  • It is not exclusively associated with neonatal necrotizing enterocolitis.
  • PI can present with or without pneumoperitoneum in BMT patients.

Purpose:

  • To describe the experience with patients diagnosed with PI after BMT.
  • To evaluate the effectiveness of conservative management for PI in this patient population.

Summary:

  • Six patients diagnosed with PI after BMT between 2000-2007 were treated conservatively.
  • All patients had a history of intestinal graft-versus-host disease and presented without peritoneal signs.
  • Treatment involved intestinal rest, antibiotics, and total parenteral nutrition, with gradual reintroduction of enteral feeding.

Impact:

  • Conservative management of PI in BMT patients, even with pneumoperitoneum, can lead to satisfactory outcomes.
  • This approach avoids surgical intervention in cases without peritonitis.
  • Parenteral nutrition and antibiotics facilitate spontaneous resolution of PI.
Abstract

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