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[Allotransplantation of Leydig cells increases serum testosterone in rats]
Jie Sun1, Cheng-Ren Shi, Ye-Bin Xi
1Department of Surgery, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. ppdrsun@gmail.com
Objective:
To observe the changes of serum testosterone after allotransplantation of Leydig cells in rats.
Methods:
Leydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times.
Results:
After allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old.
Conclusion:
Allotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.
