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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Semantic categories and relations for modelling adverse drug reactions towards a categorial structure for
Cédric Bousquet1, Béatrice Trombert, Anand Kumar
1University of Saint Etienne, Department of Public Health and Medical Informatics,St Etienne; INSERM UMR_S 872, Eq 20, Paris, France.
Abstract:
WHO-ART and MedDRA are the terminologies used in pharmacovigilance for coding of adverse drug reactions and statistical analysis. In previous work we showed that tools for automated signal detection and access to pharmacovigilance databases would benefit from terminological reasoning in order to provide improved groupings of terms describing the same medical condition. Such reasoning depends on formal definitions that are absent in both terminologies. A Categorial structure is defined as a minimal set of health care domain constraints which represents a biomedical terminology in a precise healthcare domain. Here we present a draft for a lite ontological model consisting in 19 semantic categories and 16 relations for the representation of adverse drug reactions. From this model we selected 8 semantic categories for the categorial structure. This study was restricted to WHO-ART and additional research is required in order to provide complete coverage of MedDRA.
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