Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Drug Administration and Therapy Phases: Overview

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...

Dosage Regimen: Individualization

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...

Hypertension IV: Drug Therapy and Lifestyle Modifications

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An Integrated Process for Co-Developing and Implementing Written and Computable Clinical Practice Guidelines.

American journal of medical quality : the official journal of the American College of Medical Quality·2023

Same author

An Evaluation Framework for a Novel Process to Codevelop Written and Computable Guidelines.

American journal of medical quality : the official journal of the American College of Medical Quality·2023

Same author

Multi-Method Study of Electronic Health Records Workflows.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2019

Same author

In Search of Vital Signs: A Comparative Study of EHR Documentation.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2019

Same author

Integrating Process Mining and Cognitive Analysis to Study EHR Workflow.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2017

Same author

Lessons learned from implementing service-oriented clinical decision support at four sites: A qualitative study.

International journal of medical informatics·2015

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Published on: July 7, 2023

Medication and indication linkage: A practical therapy for the problem list?

Matthew M Burton¹, Linas Simonaitis, Gunther Schadow

¹Regenstrief Institute,Indiana University School of Medicine; and Indiana University Schoolof Informatics, USA.

AMIA ... Annual Symposium Proceedings. AMIA Symposium

|November 13, 2008

Summary

This summary is machine-generated.

Medications can be automatically mapped to diseases using standard terminologies. This automated mapping enhances electronic medical record (EMR) systems for better clinical decision-making and data management.

Related Experiment Videos

Last Updated: Jun 28, 2026

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Published on: July 7, 2023

Area of Science:

Biomedical Informatics
Clinical Data Management
Health Information Technology

Background:

Electronic Medical Record Systems (EMR) benefit from structured relationships between medications and diagnoses.
Improving the problem list quality in EMRs supports enhanced clinical decision-making.

Purpose of the Study:

To evaluate the feasibility of automatically mapping medications to their indications (diagnoses) within a large-scale EMR.
To assess the accuracy of medication-indication mapping using standardized terminologies.

Main Methods:

Analysis of over 1.6 million de-identified patient records from the Regenstrief Medical Record System (RMRS).
Utilized RxNorm, VA National Drug File Reference Terminology, and SNOMED-CT (SCT) for mapping local medication and problem terms.
Evaluated linkage accuracy for medication-indication pairs.

Main Results:

Successfully mapped 24,398 medication-indication pairs.
Achieved an overall sensitivity of 67.5% and specificity of 86% for term pairs.
Adjusted for single-patient record occurrence, sensitivity was 39.5% and specificity was 97.4%.

Conclusions:

Machine-based mapping of medications to diseases/disorders is achievable using established terminology standards.
This automated mapping holds significant potential for knowledge management and decision support within EMR systems.