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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 28, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Update: molecular radiotherapy: survey and current status.

George Sgouros¹

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA. gsgouros@jhmi.edu

Cancer Biotherapy & Radiopharmaceuticals

|November 13, 2008

Summary

Molecular radiotherapy (MRT) targets cancer cells using radionuclide carriers that bind to tumor markers. This approach delivers radiation precisely, sparing healthy cells unlike traditional chemotherapy.

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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Published on: March 11, 2021

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Last Updated: Jun 28, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

Oncology
Nuclear Medicine
Molecular Biology

Background:

Molecular radiotherapy (MRT) relies on radionuclide carriers targeting tumor-associated molecules.
Advances in cancer molecular biology enable in vivo visualization for diagnosis, staging, and therapy monitoring.
These discoveries identify specific targets for precise radiation delivery at the cellular and molecular level.

Purpose of the Study:

To elucidate the principles and applications of molecular radiotherapy in cancer treatment.
To highlight the advantages of MRT over conventional chemotherapy.

Main Methods:

Systemic, intracavitary, or locoregional administration of radionuclide carriers.
Targeting of tumor-associated molecules for selective radiation delivery.

Main Results:

MRT enables precise radiation targeting to cancer cells expressing specific markers.
This contrasts with chemotherapy, which affects all proliferating cells, including healthy ones.

Conclusions:

Molecular radiotherapy offers a targeted approach to cancer treatment by exploiting molecular differences between cancer and normal cells.
MRT represents a significant advancement in precision medicine for oncology.