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Coronary artery disease and apolipoprotein A-I/C-III gene polymorphism: a study of Saudi Arabians

K Johansen1, B Dunn, J C Tan

  • 1Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Clinical Genetics
|January 1, 1991
PubMed

Insights

The 3.2-kb apolipoprotein A-I/C-III gene variant, previously linked to coronary artery disease in Caucasians, showed no significant association in Saudi Arabians. This study did not confirm previous findings in a different population group.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology

Background:

  • The 3.2-kb band in the apolipoprotein A-I/C-III polymorphic region is associated with coronary artery disease and hypertriglyceridemia in Caucasian populations.
  • Genetic predispositions to cardiovascular diseases can vary significantly across different ethnic groups.

Purpose of the Study:

  • To investigate the association between the apolipoprotein A-I/C-III gene cluster polymorphism and coronary artery disease (CAD) in a Saudi Arabian population.
  • To determine if the previously reported association of the 3.2-kb band with CAD in Caucasians is applicable to Saudi Arabians.

Main Methods:

  • Genomic DNA was extracted from 97 Saudi Arabian patients.
  • DNA was digested with Sac I and analyzed using genomic blotting with an apolipoprotein A-I gene probe.
  • Patients were classified based on coronary angiography results to determine the presence or absence of coronary artery disease.

Main Results:

  • Two hybridization bands, 4.2-kb and 3.2-kb, were observed.
  • No significant difference in genotype frequency was found between patients with and without coronary artery disease.
  • The 3.2-kb allele frequency was 16% in patients with CAD and 21% in those without, a non-significant difference.

Conclusions:

  • The study did not confirm the association between the 3.2-kb apolipoprotein A-I/C-III gene polymorphism and coronary artery disease in the studied Saudi Arabian population.
  • Genetic associations with coronary artery disease may be population-specific, highlighting the need for diverse population studies.

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