[A study of relation between changes in serum soluble intercellular adhesion molecule and infarction volume in...

To characterize relation between changes in serum soluble intercellular adhesion molecule (sICAM) and infarction volume in patients with acute cerebral infarction (ACI).

The levels of serum sICAM-1 of 165 patients with ACI were measured with enzyme linked immunosorbent assay (ELISA), and compared the results with that of 58 patients suffering from cerebral hemorrhage and 87 normal controls.

sICAM-1 in patients with ACI 24 hours after the onset [(4.73+/-0.26) mg/L] was higher than that in patients with cerebral hemorrhage [(2.81+/-0.18) mg/L] and normal controls [(2.64+/-0.25) mg/L, both P<0.01]. It was still higher than that in patients with cerebral hemorrhage and normal controls at the 14 days after the onset (both P<0.01). The levels of serum sICAM-1 were significantly higher in the patients with large cerebral infarction group [infarction volume was >10 cm(3), (5.14+/-0.34) mg/L] than in patients with medium [infarction volume was 4-10 cm(3), (4.47+/-0.20) mg/L] and small cerebral infarction groups [infarction volume was <4 cm(3), (4.12+/-0.28) mg/L, both P<0.01]. The levels of sICAM-1 were higher in patients complicated with infection compared with those without in 14 days (P<0.05 or P<0.01).

Serum sICAM-1 was closely related to cerebral infarction volume in patients with ACI.