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Related Experiment Video

Updated: Jun 28, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
08:49

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

[Delayed graft function].

A Hertig1

  • 1Service des Urgences Néphrologiques et de Transplantation Rénale, Hôpital TENON, Paris, France. alexandre.hertig@tnn.aphp.fr

Nephrologie & Therapeutique
|November 13, 2008
PubMed
Summary
This summary is machine-generated.

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Delayed graft function after kidney transplantation, often due to ischemic tubular necrosis, may benefit from antilymphocyte serum. Maintenance immunosuppression strategies must balance acute rejection risk and long-term kidney health.

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Renal medicine

Context:

  • Delayed graft function (DGF) is a common complication post-kidney transplantation.
  • Acute ischemic tubular necrosis is the primary cause of DGF, lacking specific curative treatments.
  • DGF is associated with increased risks of acute rejection and long-term renal function decline.

Purpose:

  • To review management strategies for patients experiencing delayed graft function after kidney transplantation.
  • To highlight the importance of early detection of acute rejection in DGF patients.
  • To discuss alternative immunosuppressive therapies to mitigate calcineurin inhibitor toxicity.

Summary:

  • Antilymphocyte serum induction therapy may shorten the duration of delayed kidney function.

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A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
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A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

Related Experiment Videos

Last Updated: Jun 28, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
08:49

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
07:51

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

  • Maintenance immunosuppression requires careful consideration of short-term rejection risks and long-term renal deterioration.
  • Systematic biopsies before three months are crucial for monitoring acute rejection.
  • Calcineurin inhibitor-sparing protocols, using belatacept or proliferation signal inhibitors, are recommended based on histology.

    • Impact:

    • Optimized immunosuppression can improve short-term and long-term outcomes for kidney transplant recipients with DGF.
    • Proactive management of DGF may reduce the incidence of acute rejection and preserve renal function.
    • Adherence to kidney protection measures remains essential for all transplant patients.