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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Diabetic Retinopathy

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Photoreceptors and Visual Pathways

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Related Experiment Video

Updated: Jun 28, 2026

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Retinal function and corresponding pathology in advanced retinoblastoma.

Avery H Weiss1, John P Kelly, Raj P Kapur

  • 1Division of Ophthalmology, Children's Hospital and Regional Medical Center, Seattle, WA 98105, USA.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 13, 2008
PubMed
Summary

Multifocal electroretinogram (mfERG) amplitude correlates with retinal damage in advanced retinoblastoma. A recordable mfERG suggests potential vision, while extinguished signals indicate severe damage precluding recovery.

Related Experiment Videos

Last Updated: Jun 28, 2026

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Area of Science:

  • Ophthalmology
  • Oncology
  • Medical Imaging

Background:

  • Advanced retinoblastoma presents significant challenges in assessing visual potential.
  • Histopathologic findings are crucial for understanding disease severity.
  • Localized retinal function assessment is needed to correlate with structural damage.

Purpose of the Study:

  • To correlate localized retinal function, measured by multifocal electroretinogram (mfERG), with histopathologic findings in advanced retinoblastoma.
  • To evaluate the predictive value of mfERG for visual outcomes in retinoblastoma patients.

Main Methods:

  • Retrospective review of 7 children (8 eyes) with Reese-Ellsworth stage V retinoblastoma.
  • Multifocal electroretinogram (mfERG) testing concurrent with fundus imaging.
  • Histopathologic scoring of retinal layers in enucleated eyes, centered on the optic nerve.

Main Results:

  • Severe atrophy of retinal layers was observed in 4 eyes, moderate in 2, and mild in 2.
  • mfERG amplitude directly correlated with the degree of outer retinal layer atrophy: extinguished, reduced, or mildly reduced.
  • Visual acuity at presentation was severely impaired in most cases.

Conclusions:

  • mfERG amplitude serves as a functional indicator of histopathologic retinal damage in advanced retinoblastoma.
  • A recordable mfERG suggests potential for vision, even after retinal reattachment post-chemotherapy.
  • Extinguished mfERG signals severe retinal damage, often precluding visual recovery.