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A novel role of Shc adaptor proteins in steroid hormone-regulated cancers

Syed Mahfuzul Alam1, Mythilypriya Rajendran, Shouqiang Ouyang

  • 1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5870, USA.

Endocrine-Related Cancer
|November 13, 2008
PubMed

Insights

Shc proteins link tyrosine phosphorylation and steroid signaling in cancer. The p66(Shc) protein mediates steroid action through redox signaling, offering a potential biomarker and therapeutic target for cancer prognosis.

Area of Science:

  • Molecular biology
  • Cell signaling
  • Cancer research

Background:

  • Tyrosine phosphorylation is crucial for cell growth and its dysregulation contributes to cancer.
  • Shc (Src homolog and collagen homolog) adaptor proteins are key players in tyrosine phosphorylation signaling pathways.
  • Steroids are implicated in carcinogenesis and cancer progression, with recent evidence suggesting crosstalk with tyrosine phosphorylation signaling.

Purpose of the Study:

  • To explore the role of Shc proteins, specifically p52(Shc) and p66(Shc), in steroid hormone-regulated cancers.
  • To elucidate a novel molecular mechanism involving p66(Shc)-induced redox signaling in mediating steroid action via a non-genomic pathway.

Main Methods:

  • The study discusses the established roles of Shc proteins in signaling pathways.
  • It reviews recent evidence on the crosstalk between tyrosine phosphorylation and steroid hormone action.
  • Focuses on the molecular mechanism of p66(Shc)-mediated steroid action.

Main Results:

  • Shc proteins may act as mediators between tyrosine phosphorylation and steroid signaling in cell proliferation and carcinogenesis.
  • A novel mechanism reveals that p66(Shc)-induced redox signaling mediates steroid action through a non-genomic pathway.
  • p66(Shc) shows potential as a biomarker for cancer prognosis and a therapeutic target.

Conclusions:

  • Shc proteins, particularly p52(Shc) and p66(Shc), play significant roles in steroid hormone-regulated cancers.
  • The p66(Shc) protein mediates steroid action via non-genomic redox signaling, presenting a novel therapeutic avenue.
  • p66(Shc) could serve as a valuable biomarker for predicting cancer outcomes and guiding treatment strategies.

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