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Updated: Jun 28, 2026

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Published on: March 1, 2022
The direct and indirect cost burden of Crohn's disease and ulcerative colitis
Teresa B Gibson1, Eliza Ng, Ronald J Ozminkowski
1Thomson Healthcare, Research Division, Ann Arbor, Mich 48108, USA. teresa.gibson@thomson.com
Objective:
To estimate the direct medical and indirect (absenteeism and short-term disability) cost burden of Crohn's Disease (CD) and Ulcerative Colitis (UC).
Methods:
Data were obtained from 1999 to 2005 MarketScan databases. Twelve-month expenditures for patients with CD and UC were compared to expenditures among an equal number of propensity score matched comparison group patients. Regression analysis controlled for demographics and case-mix.
Results:
Annual medical expenditures were significantly higher for commercially insured CD and UC patients compared to matched comparison group patients ($18,963 vs $5300 for CD patients, $15,020 vs $4982 for UC patients, respectively, all P < 0.001). Indirect costs were also high for employed patients with these conditions.
Conclusions:
CD and UC are costly diseases with a significant cost burden related to health care utilization and productivity loss.
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