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Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information about...
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Secondary Messengers in Hormone Action01:26

Secondary Messengers in Hormone Action

Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
Structures of the Endocrine System00:59

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...

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Updated: Jun 28, 2026

Methods to Test Endocrine Disruption in Drosophila melanogaster
09:43

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

Endocrine disrupters in the aquatic environment.

P Stahlschmidt-Allner1, B Allner, J Römbke

  • 1ECT-Oekotoxikologie GmbH, Böttgerstr. 2-14, D-65439, Flörsheim, Germany.

Environmental Science and Pollution Research International
|January 1, 1997
PubMed
Summary

Environmental chemicals like pesticides and plastics can disrupt aquatic wildlife reproduction by interfering with their endocrine systems. Further research is needed to detect these endocrine-disrupting chemicals and protect water quality.

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In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
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In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

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In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
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In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

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Related Experiment Videos

Last Updated: Jun 28, 2026

Methods to Test Endocrine Disruption in Drosophila melanogaster
09:43

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
05:47

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
04:14

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

Published on: October 6, 2023

Area of Science:

  • Environmental toxicology
  • Endocrinology
  • Aquatic biology

Background:

  • Endocrine-disrupting chemicals (EDCs) are prevalent in aquatic environments.
  • These substances can interfere with the hormonal systems of wildlife, impacting reproduction and development.

Purpose of the Study:

  • To review potential mechanisms by which various chemicals disrupt endocrine functions related to reproduction and sex differentiation in aquatic organisms.
  • To highlight the need for methods to detect EDCs and assess risks to aquatic life and drinking water.

Main Methods:

  • Review of scientific literature on known endocrine disruptors.
  • Discussion of specific examples including pharmaceuticals, agrochemicals, industrial chemicals, and plant sterols.
  • Analysis of effects on vertebrate and invertebrate endocrine systems.

Main Results:

  • Xenobiotics can disrupt endocrine systems at multiple levels, affecting pituitary control, sex differentiation, and hormone biosynthesis/catabolism.
  • Examples include phthalates, synthetic estrogens, phenylurea herbicides, plant sterols, hypolipidemic drugs, tributyltin, and PCBs.
  • Potential risks to aquatic animal reproduction and drinking water quality are identified.

Conclusions:

  • Chemicals in aquatic environments pose significant risks to reproductive health and sex differentiation in wildlife.
  • Development of detection methods for EDCs across all endocrine system levels is crucial for risk assessment and management.