Related Experiment Video
Updated: Jun 28, 2026

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System
Published on: May 10, 2020
Potential neural progenitor cells in fetal liver and regenerating liver
Fuminari Komatsu1, Imre Farkas, Hiroyasu Akatsu
1Choju Medical Institute, Fukushimura Hospital, Noyori-cho, Toyohashi, 441-8124, Japan, fkomatsu@fukuoka-u.ac.jp.
Abstract:
From unfractionated embryonic mice liver cells, appreciable amount of spherical bodies containing nestin-positive cells were generated in the presence of neuronal growth factors. Following cultivation on poly-D: -lysine/laminin-coated slips, approximately 70% of the cells expressed neuronal markers, and 16% had long processes. Functional analysis of these long-process-bearing cells with the whole-cell patch clamp method showed an inward current in response to glutamate, GABA, and serotonin as the neuronal characteristics. Furthermore, regenerating liver in adult mice also contained nestin-positive cells to the same extent as fetal liver. Regenerating liver could have potential as a source of neural cells for autologous transplantation.
Related Concept Videos
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Multipotency of Hematopoietic Stem Cells
Tissue Renewal without Stem Cells
However, failure of such a system...
Production of Formed Elements
Most HSCs commit to...
Neurogenesis and Regeneration of Nervous Tissue

