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Related Concept Videos

Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

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Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function
07:30

Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function

Published on: December 7, 2019

Cell fusion and plasticity.

Joseph J Lucas1, Naohiro Terada

  • 1Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, U.S.A.

Cytotechnology
|November 13, 2008
PubMed
Summary
This summary is machine-generated.

Somatic cell fusion is a frequent phenomenon that can complicate stem cell plasticity research. Understanding spontaneous cell fusion is crucial for accurately interpreting adult stem cell behavior and plasticity studies.

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Area of Science:

  • Stem cell biology
  • Cellular plasticity
  • Somatic cell fusion

Background:

  • Cell plasticity is a key area in stem cell research.
  • Cell fusion is increasingly recognized as a factor that can complicate the interpretation of cell plasticity, especially in adult stem cells.
  • Previous research on somatic cell fusion has highlighted its frequent occurrence and the complex cellular phenotypes it can produce.

Purpose of the Study:

  • To provide an overview of the field of somatic cell fusion.
  • To emphasize studies relevant to current research on cell plasticity.
  • To address the role of cell fusion as a confounding factor in stem cell biology.

Main Methods:

  • Literature review of "somatic cell fusion" studies.
  • Analysis of historical and contemporary research on cell fusion.
  • Synthesis of findings relevant to adult stem cell plasticity.

Main Results:

  • Spontaneous somatic cell fusion occurs with relative frequency.
  • Complex cellular phenotypes arising from cell fusion have been long-documented.
  • Cell fusion can significantly impact the interpretation of cell plasticity data.

Conclusions:

  • Somatic cell fusion is a significant consideration in stem cell plasticity research.
  • Understanding spontaneous fusion is essential for validating findings on adult stem cell plasticity.
  • Historical data on cell fusion provides valuable context for current stem cell investigations.