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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Basicity of Aliphatic Amines01:21

Basicity of Aliphatic Amines

Amines can behave as Brønsted–Lowry bases by accepting a proton from the acid to form corresponding conjugate acids. Due to a lone pair of nonbonding electrons, aliphatic amines can also act as Lewis bases by forming a covalent bond with an electrophile.
To measure the basicity of amines, two conventions are generally used. The first defines Kb as the basicity constant for the deprotonation reaction of water by the amine, as presented in Figure 1. Conventionally, lower Kb indicates higher...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...

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Updated: Jun 28, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

Lysine: Is it worth more?

D Datta1, A Bhinge, V Chandran

  • 1School of BioMedical Engineering, Indian Institute of Technology-Bombay, Powai, Mumbai, India, ddatta@cc.iitb.ac.in.

Cytotechnology
|November 13, 2008
PubMed
Summary
This summary is machine-generated.

Lysine, an essential amino acid, demonstrates significant roles beyond anabolism. This review highlights its impact on cellular proliferation, immune responses, wound healing, and angiogenesis, suggesting a unified molecular mechanism.

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Last Updated: Jun 28, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

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Application of MassSQUIRM for Quantitative Measurements of Lysine Demethylase Activity
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Application of MassSQUIRM for Quantitative Measurements of Lysine Demethylase Activity

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Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

Area of Science:

  • Biochemistry
  • Cell Biology
  • Immunology

Background:

  • Lysine is an essential cationic amino acid with a positively charged R group.
  • While its anabolic role is well-established, other biological properties remain under-explored.
  • These include roles in cellular proliferation, immune responses, wound healing, and angiogenesis.

Purpose of the Study:

  • To review and highlight the underappreciated biological properties of lysine.
  • To discuss lysine's roles in cellular proliferation, immune responses, wound healing, and angiogenesis.
  • To explore potential applications in food preservation and immunotherapy.

Main Methods:

  • Literature review of existing studies on lysine's biological functions.
  • Analysis of diverse biological effects attributed to lysine.
  • Proposal of a common molecular mechanism underlying these effects.

Main Results:

  • Lysine influences cellular proliferation both in vitro and in vivo.
  • It elicits significant inflammatory and immune responses (humoral and cell-mediated).
  • Lysine promotes accelerated healing of various wounds and induces angiogenesis.

Conclusions:

  • Lysine possesses multifaceted biological activities beyond its anabolic function.
  • These properties suggest potential therapeutic applications in wound healing and immunotherapy.
  • A unifying molecular mechanism may explain lysine's diverse biological roles.