Related Experiment Video
Updated: Jun 28, 2026

BioMEMS and Cellular Biology: Perspectives and Applications
Published on: October 1, 2007
Historical reflections on cell culture engineering
1SmithKline Beecham Pharmaceuticals, Biopharmaceutical Development, 709 Swedeland Road, King of Prussia, PA, 19406-0939, U.S.A.
Abstract:
Cell culture engineering has enabled the commercial marketing of about a dozen human therapeutic products derived from rDNA technology and numerous monoclonal antibody products as well. A variety of technologies have proven useful in bringing products to the marketplace. Comparisons of the technologies available 15 years ago are contrasted with those available today. A number of improvements in unit operations have greatly improved the robustness of the processes during the past 15 years. Further evolution of the technology is expected in several directions driven by commercial and regulatory pressures. Some problems remain for the next generation of cell culture engineers to solve.
Related Concept Videos
Cell Lines
Cell Culture
Bioreactor Controls-III
Stem Cell Culture
Scale-Up Processes
Upstream Processing

