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Updated: Jun 28, 2026

Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model
Published on: October 18, 2015
Robust emergence of small-world structure in networks of spiking neurons
Hoi Fei Kwok1, Peter Jurica, Antonino Raffone
1Laboratory for Perceptual Dynamics, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
Abstract:
Spontaneous activity in biological neural networks shows patterns of dynamic synchronization. We propose that these patterns support the formation of a small-world structure-network connectivity optimal for distributed information processing. We present numerical simulations with connected Hindmarsh-Rose neurons in which, starting from random connection distributions, small-world networks evolve as a result of applying an adaptive rewiring rule. The rule connects pairs of neurons that tend fire in synchrony, and disconnects ones that fail to synchronize. Repeated application of the rule leads to small-world structures. This mechanism is robustly observed for bursting and irregular firing regimes.
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