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Updated: Jun 28, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Interaction between the Spatiotemporal Learning Rule (STLR) and Hebb type (HEBB) in single pyramidal cells in the
Minoru Tsukada1, Yoshiyuki Yamazaki, Hiroshi Kojima
1Brain Science Center, Tamagawa University, 6-1-1, Tamagawagakuen, Machida, Tokyo, 194-8610, Japan, tsukada@eng.tamagawa.ac.jp.
Abstract:
The spatiotemporal learning rule (STLR), proposed as a non-Hebb type by Tsukada et al. (Neural Networks 9 (1996) 1357 and Tsukada and Pan (Biol. cyberm 92 (2005) 139), 2005), consists of two distinctive factors; "cooperative plasticity without a cell spike," and "its temporal summation". On the other hand, Hebb (The organization of behavior. John Wiley, New York, 1949) proposed the idea (HEBB) that synaptic modification is strengthened only if the pre- and post-cell are activated simultaneously. We have shown, experimentally, that both STLR and HEBB coexist in single pyramidal cells of the hippocampal CA1 area. The functional differences between STLR and HEBB in dendrite (local)-soma (global) interactions in single pyramidal cells of CA1 and the possibility of pattern separation, pattern completion and reinforcement learning were discussed.
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