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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Two new isoflavanones from Erythrina costaricensis
Hitoshi Tanaka1, Hisanori Hattori, Tomoko Oh-Uchi
1Faculty of Pharmacy, Meijo University, Nagoya, Japan. hitoshi@ccmfs.meijo-u.ac.jp
Abstract:
Two new isoflavanones, 5,3'-dihydroxy-4'-methoxy-5'-(3-methyl-1,3-butadienyl)-2'',2''-dimethylpyrano[5,6:6,7]isoflavanone (1) and 5,3'-dihydroxy-5'-(3-hydroxy-3-methyl-1-butenyl)-4'-methoxy-2'',2''-dimethylpyrano[5,6:6,7]isoflavanone (2), together with two known isoflavonoids, cristacarpin, and euchrenone b10, were isolated from the stems of Erythrina costaricensis. Their structures were established on the basis of spectroscopic evidence. These new compounds are rare isoflavanones, possessing both a 2,2-dimethylpyran substituent and a prenyl analog. The antibacterial activities of 1 and 2 against the methicillin-resistant Staphylococcus aureus were examined.
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