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Protective effect of vitamin C on oxidative stress: a randomized controlled trial
Shizuka Sasazuki1, Tomonori Hayashi, Kei Nakachi
1Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ssasazuk@gan2.res.ncc.go.jp
Background:
Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma.
Aim Of The Study:
Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis.
Methods:
A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C.
Results:
The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01.
Conclusion:
Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis.
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