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Updated: Jun 28, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary
Jun-Ichi Suzuki1, Daisuke Tezuka, Ryuichi Morishita
1Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. junichisuzuki-circ@umin.ac.jp
Background:
Nuclear factor-kappa B (NF-kappaB) is well known for playing a pivotal role in restenosis after percutaneous coronary intervention (PCI).
Methods And Results:
This is the first report to demonstrate an effect of NF-kappaB decoy oligodeoxynucleotides (ODN) to prevent restenosis after PCI after a 4-year observation using a coronary computed tomography (CT) scan. We showed that the decoy treatment suppressed neointimal formation after stent implantation compared to that in the same artery.
Conclusion:
Thus, for the first time, we demonstrate the clinical usefulness of the CT scan to reveal the effects of NF-kappaB decoy ODN transfer after PCI.
