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Effects of UVA and visible light on the photogenotoxicity of benzo[a]pyrene and pyrene

Céline Botta1, Carole Di Giorgio, Anne-Sophie Sabatier

  • 1Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale (EA 1784, FR 3098 - ECCOREV), Faculté de Pharmacie, Aix-Marseille Université, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France.

Environmental Toxicology
|November 13, 2008
PubMed

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Organic compounds with conjugated double bonds show strong absorption features in the UV–visible region of the electromagnetic spectrum attributed to π → π* electronic excitations. Generally, a UV–vis absorption spectrum is recorded as a plot of absorbance vs wavelength. The wavelength of maximum absorbance, which manifests as a peak in the absorption spectrum, is denoted as λmax.
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Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
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