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Updated: Jun 28, 2026

Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
Published on: September 16, 2013
Evaluation of antibacterial activity of synthetic aliphatic and aromatic monoacylglycerols
Daniela Batovska1, Iva Todorova, Stoyan Parushev
1Institute of Organic Chemistry, Centre of Phytochemistry Bulgarian Academy of Sciences, Sofia, Bulgaria. danibat@orgchm.bas.bg
Abstract:
The antibacterial activity of synthetic aliphatic and aromatic monoacylglycerols (MAGs) was studied against two human pathogens: Staphylococcus aureus and Escherichia coli. The active compounds inhibited selectively S. aureus. The most active compounds amongst them were those with medium size aliphatic chain and aromatic MAGs with electron withdrawing substituents at the aryl ring. The introduction of one or two-carbon spacer between the aryl ring and the carboxylic function did not influence antibacterial effectiveness.
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