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Imiquimod in vulvar Paget's disease: a case report
John P Geisler1, Kelly J Manahan
1Indiana Women's Oncology, Division of Gynecologic Oncology, St. Vincent Hospitals, Indianapolis, IN 46260, USA. jgeisler@indianawomensoncology.com
The Journal of Reproductive Medicine
|November 14, 2008
Summary
Topical imiquimod therapy can effectively treat recurrent vulvar Paget's disease, leading to histologic regression and sustained remission in select patients. This immune modulator offers a promising option for managing this challenging gynecologic neoplasm.
Area of Science:
- Gynecologic Oncology
- Dermatology
- Oncology
Background:
- Vulvar Paget's disease is a rare gynecologic malignancy.
- Characterized by a high rate of recurrence, posing treatment challenges.
Observation:
- An 80-year-old woman with a 12-year history of recurrent vulvar Paget's disease.
- Underwent multiple previous surgical resections for the condition.
- Received topical imiquimod therapy for histologically confirmed disease.
Findings:
- Histologic regression of vulvar Paget's disease was confirmed post-treatment.
- The patient remained disease-free at 12 months following imiquimod therapy.
- Demonstrates the efficacy of topical imiquimod in managing recurrent vulvar Paget's disease.
Implications:
- Topical imiquimod represents a viable therapeutic option for select cases of vulvar Paget's disease.
- Offers a non-surgical approach for managing recurrent or refractory vulvar Paget's disease.
- Highlights the role of immune modulators in gynecologic oncology.
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