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Polychlorinated dibenzo-p-dioxins/furans and polychlorinated biphenyls in human adipose tissue from Zhejiang
Haitao Shen1, Jianlong Han, Xiaowei Tie
1Zhejiang Provincial Center for Disease Prevention and Control, 630 Xin Cheng Road, Binjiang District, Hangzhou 310051, China. oldfishmann@hotmail.com
Abstract:
This is the first report on polychlorinated dibenzo-p-dioxin/furan (PCDD/F) and polychlorinated biphenyl (PCB) contamination of human adipose tissue from China. A total of 24 human adipose tissue samples from a general population in Zhejiang Province were analyzed for PCDD/F and PCB by high-resolution gas chromatography-high-resolution mass spectrometry. Total PCDD/F concentrations in human adipose tissue ranged from 33.9 to 504 pg g(-1)lipid (mean 108 pg g(-1)lipid). Corresponding values for dioxin-like PCBs ranged from 4.1 to 125 ng g(-1)lipid (mean 32.8 ng g(-1)lipid). Mean total WHO toxicity equivalent (TEQ) values for PCDD/Fs and PCBs in human adipose tissue were 9.22 and 16.2 pg g(-1)lipid, respectively. OCDD was the dominant PCDD/F congener, and 2,3,4,7,8-PeCDF and 1,2,3,7,8-PeCDD accounted for more than 70% of the WHO PCDD/F TEQ. In all samples, PCB-118, PCB-156 and PCB-105 were the main PCB congeners. PCB-153 concentrations were the highest of all indicator PCBs (mean 52.5 ng g(-1)lipid). The contamination levels and profiles are compared with those reported for European and Asian countries.
