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Updated: Mar 31, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
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Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

C Romeo1, B Seed

  • 1Department of Genetics, Harvard Medical School, Boston, Massachusetts.

Cell
|March 8, 1991
PubMed

We describe functional simplified T cell and Fc receptor chimeras that are capable of directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not recognized by CTL armed with the chimeras. The variety of cell types in which the native receptors are active suggests multiple possibilities for antiviral intervention through genetic means.

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