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Updated: Jun 28, 2026
04:36
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
[Hemoglobin variability in patients with chronic renal insuffiency].
1Service de néphrologie, groupe hospitalier Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 paris, France. gilbert.deray@psl.ap-hop-paris.fr
Nephrologie & Therapeutique
|November 14, 2008
Summary
Hemoglobin (HGb) levels frequently fluctuate in hemodialysis patients undergoing epoetin therapy. This HGb cycling is linked to dose changes and hospitalizations, and decreasing HGb may increase mortality risk.
Area of Science:
- Nephrology
- Hematology
Context:
- Epoetin therapy is common for anemia in hemodialysis patients.
- Recent studies highlight significant hemoglobin (HGb) level variability (cycling) in these patients.
- Hemoglobin cycling affects approximately 90% of hemodialysis patients over six months.
Purpose:
- To investigate the clinical significance and potential adverse outcomes associated with hemoglobin variability in hemodialysis patients.
- To explore factors contributing to hemoglobin cycling during epoetin therapy.
Summary:
- Hemoglobin cycling is prevalent in hemodialysis patients, with factors like epoetin dose adjustments, iron administration, and hospitalization influencing these fluctuations.
- Preliminary data suggest a correlation between decreasing hemoglobin levels and increased mortality risk.
- The study identifies epoetin dose changes, intravenous iron, and hospitalization as key factors associated with hemoglobin cycling.
Impact:
- Highlights the need for further research into the clinical consequences of hemoglobin variability in hemodialysis.
- Suggests that managing hemoglobin levels more consistently could potentially improve patient outcomes.
- Provides a basis for future studies examining interventions to stabilize hemoglobin levels and reduce mortality risk in this population.
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