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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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[Targeted treatments: which imaging?].

Nathalie Lassau1, Mohamed Chebil, Baya Benatsou

  • 1Département imagerie, Institut Gustave-Roussy, rue Camille-Desmoulins, 94805 Villejuif, France. nathalie.lassau@igr.fr

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Summary
This summary is machine-generated.

Functional imaging techniques like Dynamic Contrast Enhanced-MRI and CT-perfusion can predict early treatment response in oncology. These methods assess tumor perfusion and vascularity, offering faster insights than traditional tumor volume measurements.

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Area of Science:

  • Oncology
  • Medical Imaging
  • Radiology

Context:

  • Evaluating targeted cancer treatments is crucial.
  • Functional imaging offers new methods for assessing treatment efficacy.
  • Dynamic Contrast Enhanced-MRI, CT-perfusion, and DCE-US are key techniques.

Purpose:

  • To explore functional imaging's role in evaluating targeted cancer therapies.
  • To compare the capabilities of different functional imaging modalities.
  • To highlight the predictive power of these techniques over tumor volume changes.

Summary:

  • Dynamic Contrast Enhanced-MRI, CT-perfusion, and Dynamic Contrast Enhanced-US (DCE-US) analyze time-intensity curves to assess tumor blood flow and volume.
  • DCE-MRI and CT-perfusion uniquely evaluate capillary permeability and interstitial volume due to their contrast agents.
  • These functional imaging techniques enable earlier prediction of clinical response to targeted treatments compared to RECIST criteria.

Impact:

  • Provides earlier prediction of treatment response in oncology.
  • Enables faster clinical decision-making for targeted therapies.
  • Offers a more comprehensive assessment of tumor microenvironment compared to volumetric methods.