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Cell Size01:22

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Sensors, transducers, and effectors that regulate cell size and shape.

Mirkka Koivusalo1, Andras Kapus, Sergio Grinstein

  • 1Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

The Journal of Biological Chemistry
|November 14, 2008
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Cells must regulate their volume and shape to maintain homeostasis. This review covers the sensors, transducers, and effectors involved in cell volume regulation and response to challenges.

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Area of Science:

  • Cell Biology
  • Physiology

Background:

  • Cell volume and shape are critical parameters for cellular function and survival.
  • Maintaining cell volume homeostasis is essential, especially when cells face osmotic or mechanical stress.

Purpose of the Study:

  • This review comprehensively examines the molecular machinery responsible for sensing and responding to changes in cell volume.
  • It focuses on the sensors, transducers, and effectors that maintain cell volume homeostasis.

Main Methods:

  • Literature review of studies on cell volume regulation.
  • Analysis of molecular mechanisms underlying cellular mechanosensation and osmosensation.
  • Synthesis of information on signaling pathways involved in cell volume control.

Main Results:

  • Identified key cellular components involved in sensing cell size and shape.
  • Detailed the pathways that convey information about cell volume status.
  • Highlighted the effectors that actively counteract cell deformations.

Conclusions:

  • Cell volume regulation is a complex process involving intricate sensing, signal transduction, and effector mechanisms.
  • Understanding these components is crucial for comprehending cellular responses to environmental challenges and maintaining tissue integrity.